Persian  |  Ahvaz Jundishapur University of Medical Sciences
 
Username
Password
Register
I forgot my password

Journals Office: 2nd floor, School of Medicine Ahvaz Jundishapur University of Medical Sciences, Golestan BLV, Ahvaz - IRAN
Postal Code: 6135715794
Phone: +98-61-33738283
Fax: +98-61-33362537

Home :: Back

Advance Article Search New

jundishapur Sci Med J: 15(6); 2017; Jan-Feb: Current Issue
Article title: The Effect of Trans-Cinnamic Acid on Apoptotic Indexes in Cancer Cells MCF7

Article File:  Article(PDF) 835 Kb 
Page From: 663 To: 676      
Visit: 799

Abstract
Backgound and Objective: Trans-cinnamic acid (CA), a deamination product of phenylalanine in all plant tissues, is the main active ingredient used by the human from plant-containing foods. CA can inhibit the growth of various human tumor cell lines such as colorectal, leukemia, hematoma, as well as melanoma. This study aims to investigate the effect and action mechanism of CA on apoptosis of MCF-7 breast cancer cells. Subjects and Methods: MCF-7 breast cancer cells treated with different concentrations of CA (0, 10, 50, 100 and 200 mM) for 24 h. Cell viability was determined using MTT assay. Apoptosis markers including DNA fragmentation, phosphatidylserine exposure at the outer leaflet of the plasma membrane measured using TUNEL and flow cytometery and Annexin V affinity. Results: Viability assay showed that the IC50 of CA in MCF-7 cells was about 50 mM. CA at dose of 100 mM significantly induced the apoptosis after 24 h treatment as assessed by TUNEL+ cells and evidence of late apoptotic cells with Annexin V+ and propium iodide (PI+). [provide data here] [with P values]. Conclusion: The results showed that CA with apoptotic activity is an effective anti tumor against MCF-7 cells. CA can inhibit the growth of MCF-7 cells by inducing cell apoptosis. The results can be helpful in understanding the anticancer mechanism of CA and gain further support for its safe use as an alternative and complementary drug in cancer therapy. ►Please cite this paper as: Zeinivand F, Tabandeh MR, Kolahi M. The Effect of Trans-Cinnamic Acid on Apoptotic Indexes in Cancer Cells MCF7. Jundishapur Sci Med J 2016;15(6):663-676

Keywords:
Apoptosis, MCF-7 Cancer cell line, Trans cinnamic acid

Article Authors:
Faezeh ZeinivandFirst Author
Mohammadreza TabandehOther Author
Maryam KolahiCorresponding Author

References




کلیه حقوق این سایت متعلق به دانشگاه علوم پزشکی جندی شاپور اهواز می باشد. استفاده از مطالب این سایت با ذکر نام سایت مجاز می باشد   -   Copyright © 2012
Powered By www.itpco.net
تولید کننده سیستم های تخصصی مدیریت نشریات و همایش ها و مورد تائید وزارت بهداشت درمان و آموزش پزشکی و وزارت ارتباطات و فناوری اطلاعات و