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Jundishapur J Oncol;2015; March
Article title: Neoadjuvant Chemotherapy in Local Advanced Gastric Cancer

Article File:    Article (PDF) 610 Kb 
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Background: Gastric cancer remains a major cause of cancer death in Iran despite a significant decreasing incidence in western countries. Surgery alone has not been effective for treatment of locoregional gastric cancer because of the low rate of curative resection and high incidence of local recurrence and distant metastases. Our aim was to determine the resectability of tumor after neoadjuvant chemotherapy. Methods: Fourteen patients with clinical stage III gastric adenocarcinoma that initially seemed to be unresectable by laparoscopy were treated with three cycles of cisplatin 60 mg/m2, 5-Fluorouracil 750 mg/m2 and Epirubicin 50 mg/m2 three weeks before surgery. Results: Thirteen patients were operable for surgery after neoadjuvant chemotherapy (Pvalue= 0.001), while one patient was not operable due to developing distal metastasis. Twelve (85.85%) patients were resectable with pathologic report of R 0 and, one (7.15%) patient was reported R1, (Pvalue= 0.001). Conclusion: this study shows that neoadjuvant chemotherapy improves operability and resectability of the tumor in patients with local advanced gastric adenocarcinoma.

Gastric adenocarcinoma, Neoadjuvant chemotherapy, local advanced, Resectability

Article Authors:
Abdolhassan TalaiezadehFirst
Amir Jafar ModirgolestanOther Author
Hodjatollah ShahbazianOther Author

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